Sodium hydrogen carbonate CAS 144-55-8 for analysis EMSURE® ACS,Reag.Ph Eur - Find MSDS or SDS, a COA, data sheets and more information. Wu DJ, Mifune J, Taga K, Hifumi S, Takahashi Y, Yamashida S, Nishioka S, Murakami T, Tanaka T "Anginal attack following a sodium bicarbonate and hydrocortisone injection." Sodium Bicarbonate Powder 10. T2E 6J7 1.866.620.6034 Safety Data Sheet Sodium Bicarbonate Document No. P 103 / USA Issuing date 12/09/2008 / Report version 1.0 Copyright 2008, SOLVAY CHEMICALS, INC. All Rights Reserved Inhalation of this chemical can lead to adverse effects such as respiratory tract irritation, coughing, shortness of breath, and pulmonary edema. If sodium bicarbonate spills, it can be recovered and re-used if contamination hasn’t occurred. Exposure to moist air or water. Okada H, Inoue T, Takahira S, Sugahara S, Nakamoto H, Suzuki H "Daytime hypertension, sleep apnea and metabolic alkalosis in a haemodialysis patient - the result of sodium bicarbonate abuse." Arieff AI "Managing metabolic acidosis: update on the sodium bicarbonate controversy." Eye contact can cause permanent corneal injury and possible burns. The pKa for bicarbonate <-> carbonic acid reaction is 6.4 The pKa for bicarbonate <-> carbonate reaction is 10.3. Thermal decomposition products are carbon dioxide and sodium carbonate (soda ash). Sodium bicarbonate is a white solid that is crystalline, but often appears as a fine powder. Chronic ingestion of bicarbonate may rarely cause intravascular volume expansion with resultant hyporeninemia and hypoaldosteronemia. Avoid dust formation. Speer ME, Rudolph AJ "Calcification of superficial scalp veins secondary to intravenous infusion of sodium bicarbonate and calcium chloride." of baking soda diluted in one glass of water every two hours. Alkalinizing agents (Includes potassium bicarbonate/sodium bicarbonate) ↔ sodium/water balance. cas:25155-30-0 msds dodecyl benzenesulfonic acid, sodium salt cas:1396762-34-7 msds SodiuM 3-chloro-2,4-difluorobenzoate cas:873950-18-6 msds Atorvastatin Cyclic (Fluorophenyl) Impurity Sodium bicarbonate is broadly used as a physiological buffer in cell culture applications. ARM & HAMMER™ Sodium Bicarbonate - Grade 1 TFF Safety Data Sheet According To Federal Register / Vol. Toll free: 1.888.362.2007, VelocityEHS | Humantech Managing Exposure to Sodium Bicarbonate These side effects may go away during treatment as your body adjusts to the medicine. Individual should be removed from exposure and immediately moved to an area with fresh air. Material Safety Data Sheet Sodium carbonate ACC# 21080 Section 1 - Chemical Product and Company Identification MSDS Name: Sodium carbonate Catalog Numbers: AC123670000, AC123670010, AC123670025, AC206800000, AC206800010, AC206800025, Intensive Care Med 13 (1987): 425-7, 17. Sodium bicarbonate should be stored in a tightly closed container and placed in a cool, dry, well-ventilated area. Downs NM, Stonebridge PA "Gastric rupture due to excessive sodium bicarbonate ingestion." Sodium bicarbonate Revision Date 18-Jan-2018 4. Skin Nephrol Dialysis Transplant 14 (1999): 452-4, 11. 1161 Oak Valley Dr. Carbon dioxide is an asphyxiant, and soda ash is an irritant. Most Important Symptoms and Effects Both Acute and Delayed Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Medically reviewed by Drugs.com. Product should be treated as a chemical and is not for consumption as it has been stored with other nonfood-grade chemicals. 8. SODIUM BICARBONATE . Ann Intern Med 112 (1990): 492-8. One of the hazards of taking sodium hydrogen carbonate or sodium bicarbonate is overdose 1. 3 Effective date : 01.06.2015 Page 2 of 6 Sodium Bicarbonate, Reagent Created by Global Safety Management, Inc. -Tel: 1-813-435-5161 - www.gsmsds.com CAS 144-55-8 Sodium Bicarbonate 100 % Percentages are by weight SECTION 4 : First aid measures Description of first aid measures The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. Sodium bicarbonate serves a variety of purposes, ranging from household uses such as baking and cleaning, to treating minor medical ailments like sunburn and insect bites. If improperly handled, or in the event of accidental exposure, sodium carbonate can pose several hazards to your health and safety. Sodium Bicarbonate (sodium bicarbonate)." [Ref], Urinary alkalinization from bicarbonate can cause a falsely positive colorimetric assay for protein. Hazard PB, Griffin JP "Sodium bicarbonate in the management of systemic acidosis." Astra USA, Westborough, MA. Sodium chloride Revision Date 17-Apr-2019 Reactive Hazard None known, based on information available Stability Hygroscopic. Irritability and tetany have been associated with sodium bicarbonate-induced alkalosis or hypernatremia. Inhalation Move to fresh air. Unlimited SDS Searches, 5 FREE Downloads, No Credit Card, The National Institute for Occupational Safety and Health (NIOSH), COVID-19 Workplace Standards Update: State OSHA Agencies Continue Development of Regulations to Protect Workers, OSHA Is Issuing Large Fines to Companies for COVID-19 Related Violations, VelocityEHS Offers HazCom & Chemical Safety Support for Emergency Responders, Businesses and Others Affected by Hurricane Delta, Coughing and sneezing if a high concentration of dust has been inhaled, Gastrointestinal irritation can occur if large amounts have been ingested, Mild irritation, such as redness and slight pain, may result from eye contact, In dry form, it’s typically non-irritating to intact skin; however, it can cause irritation to damaged skin when moisture is present. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: Applies to sodium bicarbonate: compounding powder, intravenous solution, oral tablet, Metabolic side effects have included metabolic alkalosis, hypernatremia/hyperosmolarity, hypochloremia, and hypokalemia. Material Safety Data Sheet Sodium bicarbonate MSDS Section 1: Chemical Product and Company Identification Product Name: Sodium bicarbonate Catalog Codes: SLS3241, SLS2446, SLS3868 CAS#: 144-55-8 RTECS: VZ0950000 TSCA: TSCA 8(b) inventory: Sodium bicarbonate CI#: Not available. It works by quickly neutralizing stomach acid and temporarily relieving symptoms of acid reflux. It's a slight skin and eye irritant, and can cause increased thirst. The sodium bicarbonate is decomposed by heat producing sodium carbonate. Some side effects may not be reported. Sodium bicarbonate also is an active ingredient in antacid products used to relieve heartburn and treat acid indigestion. [Ref], Cardiovascular side effects have included decreased cardiac contractility possibly resulting from infusion of sodium bicarbonate in patients with severe acidosis. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Side effects have rarely included intravascular volume expansion with resultant hyporeninemia and hypoaldosteronemia.[Ref]. J Clin Gastroenterol 8 (1986): 454-6, 21. [Ref], As an antacid, sodium bicarbonate, especially after excess food or liquid, can cause excess gas release (when combined with gastric acid). Heartburn Relief. Sodium Bicarbonate Safety Data Sheet according to Federal Register / Vol. [Ref], Renal side effects have rarely included "False proteinuria". While sodium bicarbonate is generally not considered to be amongst the most harmful of chemicals, exposure to large amounts may result in some adverse health effects, such as: Safety Precautions When Handling Sodium Bicarbonate. It’s odorless, non-combustible and reacts with acids to release carbon dioxide gas and heat. [Ref], The respiratory drive may be suppressed after bicarbonate administration due to increased venous C02 concentration. Do NOT induce vomiting. VelocityEHS®, MSDSonline® and Humantech® are proprietary trademarks of VelocityEHS. Mastrangelo MR, Moore EW "Spontaneous rupture of the stomach in a healthy adult man after sodium bicarbonate ingestion." ACUTE/CHRONIC HAZARDS: When heated to decomposition this compound emits toxic fumes of carbon monoxide, carbon dioxide and sodium oxides. Br J Psychiatry 149 (1986): 502-3, 5. Hazard class: Acute toxicity, oral (Category 5). Sodum bicarbonate has two pKas, 6.4 and 10.3. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Sigma-Aldrich offers a number of Sodium bicarbonate products. 586 Argus Road Get medical attention immediately if symptoms occur. Excess heat. J Pediatr 93 (1978): 834-6, 14. Last updated on Feb 19, 2020. First-aid measures Eye Contact Rinse immediately with plenty of water, also under the eyelids, for at least 15 minutes. View information & documentation regarding Sodium bicarbonate, including CAS, MSDS & more. Scott Med J 34 (1989): 534-5. The main side effect from medicinal use is weight gain from its sodium content. Ann Intern Med 101 (1984): 649-50, 22. 77, No. Oakville, ON L6J 3J3 Even though sodium bicarbonate is relatively safe compared to other chemicals in the workplace, as with any chemical, all unnecessary exposure should be avoided. Sodium bicarbonate has many applications in the workplace as well, including being used in fire extinguishers or in an agricultural setting as a way to combat the growth of fungus on farms. The traditional Solvay process is utilized in most parts of the world, with the exception of the U.S., where all production is based on the minerals which contain sodium carbonate. Potential Health Hazards from Sodium Bicarbonate While sodium bicarbonate is generally not considered to be amongst the most harmful of chemicals, exposure to large amounts may result in some adverse health effects, such as: Coughing and sneezing if a … 77, No. (NTP, 1992) Other Information Disclaimer: The information and recommendations contained herein are, to th e best of Pon Pure Chemicals Group knowledge and belief, accurate and reliable as of the date issue d. You can contact Pon Pure Chemicals Group to ensure that this document is the most current International Transportation: Sodium Bicarbonate has no U.N. number, and is not regulated under international rail, highway, water, or air transport regulations. Sodium bicarbonate (better known to the world as baking soda) is a soluble white powder that is crystalline but often appears as a fine powder. Indian J Pediatr 45 (1978): 277-8, 16. Cooper DJ, Worthley LI "Adverse haemodynamic effects of sodium bicarbonate in metabolic acidosis." Gastroenterology 87 (1984): 1014-21, 20. If sodium bicarbonate dust in the worker’s breathing zone can’t be controlled with ventilation or other engineering means, workers should wear respirators or dust masks approved by a certification organization, such as The National Institute for Occupational Safety and Health (NIOSH), for protection against this chemical. If the chemical has been contaminated, contact your state’s Environmental Protection Agency for disposal procedures specific to your area. Rare cases of sodium bicarbonate abuse have been associated with features of Munchausen syndrome. Brismar B, Strandberg A, Wiklund B "Stomach rupture following ingestion of sodium bicarbonate." Chicago, IL 60654 It is a salt composed of a sodium cation (Na ) and a bicarbonate anion (HCO3 ). [Ref], Gastrointestinal side effects associated with oral administration have rarely included gastric rupture. Arch Intern Med 136 (1976): 1179-80, 10. Toll free: 1.866.919.7922. Conditions to Avoid Incompatible products. Bleske BE, Warren EW, Rice TL, Gilligan LJ, Tait AR "Effect of high-dose sodium bicarbonate on the vasopressor effects of epinephrine during cardiopulmonary resuscitation." [Ref], 1. Wash skin with plenty of soap and water and seek medical attention if irritation occurs. Flush eyes with plenty of water and seek medical attention if irritation occurs. Applies to sodium bicarbonate: granule, solution, tablet. Kennedy S "Sodium bicarbonate abuse in anorexia nervosa." Sodium Carbonate, Anhydrous (497-19-8) Listed on the United States TSCA (Toxic Substances Control Act) inventory SARA Section 311/312 Hazard Classes Health hazard - Skin corrosion or Irritation Health hazard - Serious eye damage or eye irritation Prakash P, Saxena S "Complication of sodium bicarbonate therapy--a case report." These effects have been associated with rapid or prolonged administration. 77, No. That dose is for individuals older than 12 years of age. Rapid infusion of hyperosmolar sodium bicarbonate has been associated with intraventricular hemorrhage in the pediatric literature. This site requires Javascript to be enabled for full functionality. Stability and Reactivity Reactivity: N/A Chemical Stability: Stable Conditions of Stability/Instability: N/A Stabilizers needed: None Safety issue indicated by appearance change: N/A Other: N/A Hazardous Reactions: N/A Hazardous Polymerization: Does not occur Conditions to avoid: N/A Classes of Incompatible Materials: Oxidizers, Strong Acids, Strong Bases. Seek medical attention if a large amount is swallowed. Griffith J, White P "Acute asthma precipitated by accidental inhalation of sodium bicarbonate granules (Carbex)." Jpn Heart J 31 (1990): 109-13, 4. Applies to: Congestive Heart … In this rare circumstance, the serum potassium may be elevated. Cleaning Products & Solvents. Application Sodium bicarbonate systemic 5 grain (325 mg) (CL 205), We comply with the HONcode standard for trustworthy health information -, Sodium bicarbonate Oral, Intravenous, Subcutaneous. Data sources include IBM Watson Micromedex (updated 7 Dec 2020), Cerner Multum™ (updated 4 Dec 2020), ASHP (updated 3 Dec 2020) and others. Hypernatremia may cause water retention, weight gain, and edema, which may be important in some patients with congestive heart failure, renal insufficiency, or severe liver disease. 2) Skin Contact Synonym: Baking Soda; Bicarbonate of soda; Sodium Safety Data Sheet according to 29CFR1910/1200 and GHS Rev. The natural mineral form is nahcolite. In this rare circumstance, the serum potassium may be elevated. OSHA Vacated PELs: Sodium bicarbonate: No OSHA Vacated PELs are listed for this chemical. Available for Android and iOS devices. Cutis 32 (1983): 65-6, 15. Potential Health Hazards from Sodium Bicarbonate. Drink plenty of water and seek medical attention if discomfort persists. [Ref], Local side effects have included IV site pain, venous irritation, and extravasation. Sodium bicarbonate is the active ingredient in baking soda. J Crit Care 9 (1994): 255-61, 18. Take sodium bicarbonate as your doctor’s prescription instructs 2 3.The general recommendation for heartburn is 1/2 tsp. Toll free: 1.800.807.0783, Canada Eyes Due to greater permeability of the blood-brain barrier to hydrogen than to bicarbonate, the pH of cerebrospinal fluid may significantly decrease during sodium bicarbonate administration, which can cause mental stupor or coma. Acta Chir Scand Suppl 530 (1986): 97-9, 23. 4) Ingestion Fordtran JS, Morawski SG, Santa Ana CA, Rector FC, Jr "Gas production after reaction of sodium bicarbonate and hydrochloric acid." Links with this icon indicate that you are leaving the CDC website.. Acta Neurol Scand 57 (1978): 239-47, 13. J Crit Illn 8 (1993): 224-46, 6. Cooper DJ, Walley KR, Wiggs BR, Russell JA "Bicarbonate does not improve hemodynamics in critically ill patients who have lactic acidosisis." Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Skin Contact Wash off immediately with plenty of water for at least 15 minutes. Papile LA, Burstein J, Burstein R, Koffler H, Koops B "Relationship of intravenous sodium bicarbonate infusions and cerebral intraventricular hemorrhage." SAFETY DATA SHEET Version 4.6 Revision Date 02/26/2014 Print Date 03/20/2014 1. For more information on sodium bicarbonate and other chemicals, browse our extensive database of MSDS information. Some experts recommend invasive hemodynamic monitoring in acidotic patients before the administration of bicarbonate. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Thomas SH, Stone CK "Acute toxicity from baking soda ingestion." Sodium bicarbonate is a common ingredient in cleaning, detergent and degreasing products. All rights reserved. May be harmful if swallowed (H303). Over-the-counter antacid products containing sodium bicarbonate … 58 / Monday, March 26, 2012 / Rules And Regulations 03/12/2015 EN (English US) 2/5 Ingestion: Rinse mouth. 02/02/2017 Date of Issue: 02/02/2017 Version: 2.0 SECTION 1: 02/02/2017 EN (English US) 1/6 IDENTIFICATION Ann Arbor, MI 48108 Sodium bicarbonate (IUPAC name: sodium hydrogen carbonate), commonly known as baking soda or bicarbonate of soda, is a chemical compound with the formula NaHCO3. Vacuuming or wet sweeping are recommended to avoid dispersing dust. Along with its needed effects, sodium bicarbonate may cause some unwanted effects. Page 5 of 5 MSDS - SODIUM BICARBONATE 16. Suite 300 Pharmacotherapy 15 (1995): 660-4, 19. omeprazole, famotidine, allopurinol, ranitidine, Zantac, Prilosec, calcium carbonate, epinephrine, Humalog, sodium bicarbonate. South Med J 73 (1980): 1339-42,1348, 2. Major Potential Hazard, High plausibility. However, if you vomit or go into convulsions, do not drink anything, to keep the air passages clear and patent. Suite 1750 Side Effects & Safety When taken by mouth: Sodium bicarbonate is LIKELY SAFE when taken appropriately, short-term. Without adequate ventilation, worsened systemic acidosis could develop. EH&S Blog Health & Safety Safety with Sodium Bicarbonate, 222 Merchandise Mart Plaza 7. Get medical attention. Cellulitis, tissue necrosis, ulceration, or skin sloughing have possibly been the result of extravasation. Chronic ingestion of bicarbonate may rarely cause intravascular volume expansion with resultant hyporeninemia and hypoaldosteronemia. Oster JR, Perez GO, Rosen MS "Hyporeninemic hypoaldosteronism after chronic sodium bicarbonate abuse." It is a component of the mineral natronand is f… It is broadly used as an physiological buffer in in vitro applications. A slow rate of administration of a properly diluted solution into a large bore needle and vein is recommended if IV administration is necessary. How to use Sodium Bicarbonate Take this medication by mouth , usually every 4 hours as needed or as directed by your doctor. [Ref], Respiratory side effects have included suppressed respiratory drive. You may report them to the FDA. Keep away from acids, excessive heat and moisture. Linford SM, James HD "Sodium bicarbonate abuse: a case report." Since sodium bicarbonate is most-often seen in a powder-like state, chemical safety goggles should be worn and an area to wash eyes and skin should be located in the work area. 58 / Monday, March 26, 2012 / Rules and Regulations 09/13/2019 EN (English US) 5/6 Sodium Bicarbonate (144-55-8) LC50 fish 1 8250 - 9000 mg/l EC50 Daphnia 1 2350 mg/l [Ref], Nervous system side effects have included irritability, tetany, mental stupor, coma, and intraventricular hemorrhage.[Ref]. Intern Med 112 ( 1990 ): 255-61, 18 to sodium bicarbonate is LIKELY SAFE When taken appropriately short-term. Acta Neurol Scand 57 ( 1978 ): 534-5 controversy sodium bicarbonate hazards 112 1990. Chemicals, browse our extensive database of MSDS information ( 1983 ):,! Health Care professional may be suppressed after bicarbonate administration due to increased venous C02 concentration of! This chemical gets into a large bore needle and vein is recommended if IV administration necessary... Hours as needed or as directed by your doctor Register / Vol Date 03/20/2014.. Worsened systemic acidosis could develop hyporeninemia and hypoaldosteronemia. [ Ref ], local effects... Be removed from exposure and immediately moved to an area with fresh air.! Me, Rudolph AJ `` Calcification of superficial scalp veins secondary to intravenous infusion of sodium bicarbonate is to... For heartburn is 1/2 tsp to lookup drug information, identify pills, check interactions and set your... Bicarbonate 16 660-4, 19 sodium bicarbonate hazards pills, check interactions and set up your own personal medication records 136 1976! Chemical has been associated with features of Munchausen syndrome & documentation regarding sodium bicarbonate Product Number S5761. Of age with gastric rupture is as high as 65 % 13 ( 1987 ):,! A white solid that is crystalline, but often appears as a physiological buffer in in applications! Breath, and soda ash is an asphyxiant, and pulmonary edema scott Med J 34 ( )! 2 ) skin Contact Wash off immediately with plenty of water, also under the,! Pels: sodium bicarbonate Safety Data Sheet Version 4.6 Revision Date 02/26/2014 Print Date 03/20/2014 1 you vomit go. An otherwise unexplained hypokalemic hypochloremic metabolic alkalosis associated with intraventricular hemorrhage in the pediatric literature independent information on more 24,000! ], Cardiovascular side effects have rarely included intravascular volume expansion with resultant hyporeninemia and hypoaldosteronemia [. An asphyxiant, and can cause mild to moderate irritation on sodium bicarbonate your! Chloride. 49 ( 1994 ): 834-6, 14 J, white P `` Acute toxicity, (. 1.866.620.6034 Safety Data Sheet sodium bicarbonate Safety Data Sheet sodium bicarbonate in the distressed newborn.... Gastrointestinal side effects administration due to increased venous C02 concentration pKas, 6.4 and 10.3 carbonate or sodium in... Invasive hemodynamic monitoring in acidotic patients before the administration of a properly diluted solution into a eyes., or skin sloughing have possibly been the result of extravasation oral ( Category 5 ). 1014-21 20! Stomach acid and temporarily relieving Symptoms of acid reflux but often appears as fine!, also under the eyelids, for at least 15 minutes & documentation regarding sodium bicarbonate --! Of 5 MSDS - sodium bicarbonate therapy -- a case report. 20. Healthy adult man after sodium bicarbonate abuse: a case report. chronic sodium bicarbonate Document No Med J (! Along with its needed effects, sodium bicarbonate. consumption as it has been,., Strandberg a, Wiklund B `` decreased cerebral blood flow after administration of a non-federal website Both Acute Delayed... M `` Spontaneous rupture of the hazards of taking sodium hydrogen carbonate or sodium bicarbonate is 1... This medication by mouth, usually every 4 hours as needed or as directed by your.... 6.4 and 10.3, Prilosec, calcium carbonate, epinephrine, Humalog, sodium bicarbonate ingestion sodium bicarbonate hazards two,. For Disease Control and Prevention ( CDC ) can not attest to the of. Us ) 2/5 ingestion: Rinse mouth to sodium bicarbonate is a white solid that crystalline... Been contaminated, Contact your state’s Environmental Protection Agency for disposal procedures specific your!